What is the mechanism of action of bromocriptine div ol li strong Dopaminergic Modulation strong ul li Bromocriptine primarily acts on dopamine receptors in the hypothalamus By doing so it modulates the release of gonadotropin-releasing hormone GnRH which is a key regulator of the reproductive system li li Gonadotropins such as follicle-stimulating hormone FSH and luteinizing hormone LH play a crucial role in ovarian stimulation during fertility treatments By influencing the release of GnRH Bromocriptine indirectly affects the secretion of these gonadotropins li ul li li strong Reduction in LH Surge strong ul li One of the triggers for OHSS is the exaggerated surge in LH that occurs during the final stages of ovarian stimulation This LH surge can lead to the release of a large number of eggs and an increase in vascular permeability in the ovaries contributing to the development of OHSS li li Bromocriptine may help to mitigate this LH surge preventing the ovaries from becoming overly sensitive to the hormonal signals that induce hyperstimulation li ul li li strong Prevention of Excessive Ovarian Response strong ul li Fertility treatments aim to stimulate the ovaries to produce multiple follicles and eggs However in some cases the ovaries may respond excessively leading to the production of a large number of eggs li li Bromocriptine by modulating the dopaminergic tone may help to prevent an exaggerated ovarian response reducing the likelihood of an excessive number of eggs maturing during the treatment cycle li ul li li strong Vascular Stability strong ul li OHSS is associated with increased vascular permeability leading to the accumulation of fluid in the abdominal cavity and other tissues Bromocriptine’s influence on the hormonal milieu may contribute to better vascular stability helping to minimize fluid leakage and the development of severe OHSS li ul li ol… Read More »