Bromocriptine is a dopamine receptor agonist that is commonly used to treat hyperprolactinemia, a condition characterized by elevated levels of prolactin in the blood. Prolactin is a hormone produced by the pituitary gland, and its primary function is to stimulate milk production in the mammary glands. Elevated prolactin levels can have various effects on reproductive health, including disruptions to the menstrual cycle and ovulatory dysfunction in women and reduced testosterone levels in men.

To prevent lactation and production of breast milk, one tablet is taken twice daily for 2 weeks. Sometimes milk production will start again 2 or 3 days after the medicine is stopped. 76.1% of patients showed positive signs for pregnancy following bromocriptine treatment

Here’s how dopamine receptor agonists like Bromocriptine work to address hyperprolactinemia and, in turn, help improve fertility:

1. Dopamine Regulation:
   • Dopamine is a neurotransmitter that plays a crucial role in inhibiting the release of prolactin. The secretion of prolactin is normally suppressed by dopamine from the hypothalamus.
   • In hyperprolactinemia, there is an excess of prolactin due to decreased dopamine activity or increased prolactin-stimulating factors. Dopamine receptor agonists like Bromocriptine mimic the action of dopamine, helping to regulate prolactin secretion.
2. Restoration of Dopaminergic Balance:
   • Bromocriptine acts on dopamine receptors in the pituitary gland, restoring a more balanced dopaminergic tone. By doing so, it reduces the excessive secretion of prolactin.
3. Normalization of Prolactin Levels:
   • By normalizing prolactin levels, Bromocriptine helps to correct the hormonal imbalances caused by hyperprolactinemia. This, in turn, contributes to the restoration of normal menstrual cycles and ovulatory function in women.
4. Improvement in Fertility:
   • For women with hyperprolactinemia-related menstrual irregularities or anovulation, the normalization of prolactin levels with Bromocriptine can lead to improved fertility. Once ovulation is restored, the chances of conception increase.

It’s important to note that while Bromocriptine and other dopamine agonists can be effective in treating hyperprolactinemia and improving fertility in certain cases, their use should be carefully monitored by a healthcare professional. The dosage needs to be adjusted based on individual response, and ongoing evaluation is necessary to ensure the effectiveness of treatment.

Additionally, the underlying cause of hyperprolactinemia should be investigated, as it can be due to various factors such as a pituitary tumor (prolactinoma). Treatment may vary based on the specific diagnosis and individual health considerations. Always consult with a healthcare provider for personalized advice and management of fertility-related concerns

Verified by: Rami Diab (December 19, 2023)

Citation: Rami Diab. (December 19, 2023). Can I get pregnant after treating high prolactin with Bromocriptine. Medcoi Journal of Medicine, 1(2). urn:medcoi:article22604.