Nutrition facts and Nutritional information of Quercetin

Nutrition facts and Nutritional information of Quercetin

Nutrition facts and Nutritional information of Quercetin

Quercetin (also known as flavonoid quercetin, الكويرسيتين) is a potent natural compound renowned for its disease-fighting properties. It is primarily found in onions and is available in supplement form, offering efficacy comparable to many pharmaceutical drugs.

Overview

Quercetin belongs to several plant pigments called flavonoids that are found in many vegetables and fruits.

Flavonoids, a class of natural compounds abundant in fruits and vegetables, exert profound effects on apoptosis, the programmed cell death crucial for maintaining cellular homeostasis. Quercetin, a prominent flavonoid, has garnered attention for its potential therapeutic benefits, particularly in cardiovascular diseases and cancer. However, the precise mechanisms underlying its effects on apoptosis and disease prevention remain the subject of ongoing research.

Apoptosis, orchestrated by intricate signaling pathways and regulated by various cellular components, plays a pivotal role in eliminating damaged or dysfunctional cells, thereby safeguarding tissue integrity and function. Flavonoids, including quercetin, exert modulatory effects on apoptosis by influencing intracellular DNA integrity and signaling cascades, thereby impacting cellular fate and disease progression.

Current studies are focused on elucidating the specific mechanisms through which quercetin and other antioxidants modulate apoptosis and mitigate disease risk. Researchers and clinicians remain optimistic about the potential therapeutic implications of these findings in combating cardiovascular diseases and cancer, two leading causes of morbidity and mortality worldwide.

By unraveling the intricate interplay between flavonoids, apoptosis, and disease pathogenesis, this research aims to pave the way for novel therapeutic strategies targeting these pathways. Through a comprehensive understanding of the molecular mechanisms underlying quercetin’s actions, clinicians can harness its therapeutic potential to improve patient outcomes and mitigate the burden of chronic diseases.

Quercetin, a flavonoid abundant in fruits and vegetables, exerts diverse physiological effects through intricate interactions with cellular components.

1. Interaction with Cellular Components:

Quercetin interacts with various cellular components, including DNA, proteins, organelles, and signaling molecules, modulating their functions and signaling cascades.

Within the nucleus, quercetin interacts with DNA through hydrogen bonding and hydrophobic interactions, influencing DNA stability and conformation.

2. Effects on DNA Integrity:

Quercetin exhibits both pro-oxidant and antioxidant properties, leading to its dual effects on DNA integrity.

At lower concentrations, quercetin acts as an antioxidant, scavenging free radicals and protecting DNA from oxidative damage.

Conversely, at higher concentrations or under certain conditions, quercetin can induce oxidative stress, leading to DNA damage, strand breaks, and alterations in gene expression.

3. Modulation of Apoptosis:

Quercetin modulates apoptosis, the programmed cell death process crucial for maintaining tissue homeostasis and eliminating damaged cells.

Through its interactions with apoptotic signaling pathways, quercetin influences the expression of pro-apoptotic and anti-apoptotic genes, ultimately promoting or inhibiting cell death as needed.

4. Regulation of Oxidative Stress:

Quercetin exerts antioxidant effects by scavenging reactive oxygen species (ROS) and enhancing the activity of endogenous antioxidant enzymes.

Additionally, quercetin modulates redox-sensitive signaling pathways, such as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, to regulate cellular oxidative stress responses.

5. DNA Repair Pathways:

Quercetin affects DNA repair pathways, including base excision repair (BER), nucleotide excision repair (NER), and homologous recombination (HR), which are essential for maintaining genomic integrity.

By enhancing DNA repair enzyme activity and promoting DNA damage recognition, quercetin facilitates the repair of DNA lesions induced by oxidative stress or environmental factors

Quercetin’s multifaceted interactions with intracellular DNA and cellular components highlight its potential as a therapeutic agent in various disease conditions. Ongoing research into the role of quercetin and flavonoids in apoptosis holds promise for advancing our understanding of disease pathogenesis and identifying targeted therapeutic interventions.

Quercetin, a flavonoid with potent antioxidant and anti-inflammatory properties, has garnered attention for its potential therapeutic effects in various health conditions, including allergies and cardiovascular diseases.

1. Allergic Reactions:

In vitro studies investigating allergen-induced allergic reactions have demonstrated the ability of quercetin to mitigate clinical symptoms, particularly facial swelling and lip edema.

Quercetin exerts its anti-allergic effects by modulating inflammatory pathways, including the release of histamine and other pro-inflammatory mediators involved in allergic responses.

2. Cardiovascular Health:

Animal studies exploring the cardiovascular benefits of quercetin-rich foods, such as burgundy or merlot wine, have shown promising results in reducing the risk of atherosclerosis, a hallmark of heart disease.

High concentrations of quercetin in these beverages have been associated with decreased oxidative stress, inflammation, and endothelial dysfunction, all of which contribute to the development and progression of atherosclerosis.

3. Mechanistic Insights:

The anti-allergic effects of quercetin involve inhibition of mast cell degranulation, suppression of IgE-mediated allergic responses, and modulation of NF-kB and MAPK signaling pathways.

In the context of cardiovascular health, quercetin exerts protective effects by enhancing endothelial function, inhibiting LDL oxidation, and reducing vascular inflammation.

4. Clinical Implications:

The findings from these preclinical studies provide valuable insights into the therapeutic potential of quercetin-rich foods and supplements in managing allergic reactions and mitigating cardiovascular risk factors.

Further clinical research is warranted to validate these findings and explore the optimal dosage and formulation of quercetin for maximizing its therapeutic benefits in human subjects.

Quercetin emerges as a promising natural compound with diverse health benefits, ranging from alleviating allergic symptoms to protecting against cardiovascular diseases. Understanding the underlying mechanisms of quercetin’s actions is essential for harnessing its full therapeutic potential and improving human health outcomes

Atherosclerosis poses a significant threat to cardiovascular health, characterized by the accumulation of fatty plaques within arterial walls, predisposing individuals to coronary events and stroke. Emerging research suggests that certain nutrients, particularly flavonoids, may hold promise in mitigating the progression of atherosclerosis and reducing the risk of cardiovascular events[1]. Below is a review outlining the potential therapeutic benefits of flavonoid supplementation, along with considerations regarding dosage for maximizing efficacy:

1. Mechanisms of Action:

Flavonoids exhibit a range of bioactive properties, including antioxidant, anti-inflammatory, and anti-atherogenic effects.

These compounds have been shown to attenuate oxidative stress, inhibit LDL oxidation, suppress inflammatory pathways, and promote endothelial function, all of which play critical roles in the development and progression of atherosclerosis.

2. Potential Benefits:

Preclinical studies have demonstrated the potential of flavonoids to mitigate atherosclerotic plaque formation, stabilize vulnerable plaques, and improve vascular function.

Flavonoid-rich foods and supplements have been associated with reduced cardiovascular risk factors, including lower LDL cholesterol levels, improved lipid profiles, and enhanced arterial health.

3. Dosage Considerations:

While promising, the dosages of flavonoids tested in preclinical studies often exceed those achievable through dietary intake alone.

Supplementation with flavonoid-rich extracts or concentrates may be necessary to achieve therapeutic effects, particularly in individuals at high risk of cardiovascular disease.

Ongoing research aims to identify optimal dosage regimens and formulations that balance efficacy with safety, ensuring maximal benefit while minimizing potential adverse effects.

4. Future Directions:

Continued research is needed to elucidate the precise mechanisms underlying the cardiovascular effects of flavonoids and to establish evidence-based recommendations for their use in clinical practice.

Long-term clinical trials are warranted to assess the efficacy, safety, and long-term outcomes of flavonoid supplementation in individuals with or at risk of atherosclerosis.

Flavonoids hold promise as adjunctive therapies for the prevention and management of atherosclerosis and associated cardiovascular complications. However, further research is needed to optimize dosage regimens and determine their role in clinical practice. Collaboration between researchers, clinicians, and industry stakeholders is essential to advance our understanding of flavonoid therapy and its potential impact on cardiovascular health

Fighting High Cholesterol

Research conducted in test tubes has demonstrated the potential of quercetin to mitigate the damaging effects of LDL cholesterol. However, further studies are warranted to validate these findings. Additionally, laboratory investigations are underway to assess whether quercetin supplementation could effectively combat hypertension.

Fighting Interstitial Cystitis and Prostatitis

Two small-scale studies have suggested potential benefits of flavonoids for women with interstitial cystitis, a condition characterized by bladder pain and urgency to urinate. While it’s unclear which symptoms may be effectively treated by quercetin, it has shown broad-spectrum benefits in combating urinary tract infections.

Furthermore, research indicates that quercetin flavonoids aid in fighting prostatitis. However, these findings are based on studies involving a limited number of volunteers, and further evaluation of the collected data is warranted [2].

The natural combat against Rheumatoid Arthritis (RA) using quercetin-rich fruits has been established. However, attributing the results solely to a single antioxidant remains unsupported.

Quercetin, along with other flavonoids derived from or present in fruits and vegetables, has shown promise in cancer prevention. Incorporating these compounds into one’s diet is recommended for individuals seeking to reduce their risk of certain types of cancer. Nonetheless, further research is required to fully elucidate their mechanisms and potential benefits.

Dietary Sources

Quercetin is primarily sourced from vegetables and fruits, particularly citrus fruits, apples, onions, parsley, burgundy, and merlot wine. Olive oil, grapes, and dark berries like blueberries, blackberries, and bilberries are also rich in flavonoids, including quercetin.

Available Forms of quercetin:

Quercetin can be obtained from an enzyme found in pineapple, bilberry, and green tea extract. Additionally, water-soluble forms of quercetin are available.

How to Go on it:

Pediatric  ++
Adult  +++++

Precautions

Quercetin is generally considered safe with no proven side effects. Athletes often use quercetin products for muscle building due to its perceived safety compared to other amino acids[3].

However, excessive intake of quercetin, particularly doses exceeding 1 gram per day, may impact intracellular protein functions and protein synthesis, potentially leading to increased muscle mass. There have been unproven reports of kidney harm associated with high doses of quercetin. It is advisable to consume quercetin supplements in moderation and consult with a healthcare professional before starting any new supplementation regimen.

Possible Interactions

If you are currently taking any of the following medications, use caution and consult with your doctor before taking quercetin.

  • Warfarin (Coumadin)
  • Clopidogrel (Plavix)
  • Aspirin.

Quercetin may enhance the effects of these drugs, increasing the risk of bleeding.

If you are on corticosteroids, quercetin may prolong the duration of these drugs in your body.

For individuals taking cyclosporine (an antibiotic), quercetin may interfere with the absorption of the drug, potentially compromising the immune system.

Excessive use of quercetin in conjunction with medications metabolized by the liver may alter the metabolism of these medications. It is advisable to consult with your healthcare provider before starting quercetin supplementation.

Verified by: Dr.Diab (April 5, 2024)

Citation: Dr.Diab. (April 5, 2024). Nutrition facts and Nutritional information of Quercetin. Medcoi Journal of Medicine, 5(2). urn:medcoi:article15671.

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