How to Treat Cushings Disease Cushings syndrome (ectopic Acth syndrome) is a pituitary-dependent adrenal disorder caused by overactive adrenal tumors, it is characterized by hypercortisolism, which is a condition of biochemical cortisol excess. Less commonly, Bilateral ACTH-independent macronodular adrenocortical hyperplasia (AIMAH) may lead to Cushing syndrome. [2][3][4] Cortisol production is regulated by pituitary Acth (adrenocorticotropic hormone)……. Read More »