What are the affects of quercetin and its active compounds on aging

Quercetin is a flavonoid and phytochemical found in many fruits, vegetables, and herbs. It is a potent antioxidant, anti-inflammatory, and anti-aging compound that has been shown to have many health benefits.

Here are some of the active anti-aging, anti-inflammatory, and antioxidant compounds in quercetin:

1. Antioxidants: Quercetin is a powerful antioxidant that scavenges free radicals, which can cause oxidative stress and damage to cells.
2. Anti-inflammatory compounds: Quercetin has been shown to inhibit the production of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).
3. Enzyme inhibitors: Quercetin inhibits the activity of enzymes that produce inflammatory compounds, such as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX).
4. Histamine inhibitors: Quercetin has been shown to inhibit the release of histamine, which can cause allergy symptoms such as sneezing, itching, and swelling.
5. DNA protectors: Quercetin has been shown to protect DNA from oxidative damage, which can lead to cellular aging and disease.

Quercetin promotes antioxidant activity and reduces inflammation by several mechanisms:

1. Scavenging free radicals: Quercetin can neutralize free radicals and prevent them from damaging cells.
2. Inhibiting inflammatory cytokines: Quercetin can inhibit the production of pro-inflammatory cytokines, which can reduce inflammation.
3. Inhibiting enzymes: Quercetin can inhibit the activity of enzymes that produce inflammatory compounds, such as COX-2 and LOX.
4. Inhibiting histamine release: Quercetin can inhibit the release of histamine, which can reduce allergy symptoms and inflammation.
5. Protecting DNA: Quercetin can protect DNA from oxidative damage, which can reduce cellular aging and disease.

Quercetin is a powerful anti-aging, anti-inflammatory, and antioxidant compound that can promote cellular health and reduce the risk of many chronic diseases.

The optimal dose of quercetin used in clinical trials varies depending on the condition being studied. However, the typical dose range for most studies is between 500 and 1000 milligrams per day.

The optimal dosing for various conditions are as follows:

• For anti-inflammatory and antioxidant effects: 500-1000 milligrams per day.
• For cardiovascular health: 500-1000 milligrams per day.
• For exercise performance and recovery: 1000 milligrams per day.
• For allergies and asthma: 500-1000 milligrams per day.
• For metabolic disorders such as obesity and diabetes: 500-1000 milligrams per day.

It is important to note that these dosages may not be appropriate for everyone and should be discussed with a healthcare provider before starting any supplement regimen. Additionally, the quality and purity of the supplement can also affect its efficacy, so it is important to choose a reputable brand.

Verified by: Dr.Diab (April 5, 2024)

Citation: Dr.Diab. (April 5, 2024). What are the affects of quercetin and its active compounds on aging. Medcoi Journal of Medicine, 6(2). urn:medcoi:article21695.