Why women with Complete Involution are Less Likely to Develop Breast Cancer

What Factors Determine the Density and Size of the Mammary Glands

The mammary glands are organs in the female body responsible for producing milk to nourish newborns. Their development and morphology are influenced by several factors, including genetics, hormones, age, and pregnancy history.

During puberty, hormones such as estrogen and progesterone stimulate the growth and development of the mammary glands. Genetics also play a role in determining the size and density of the mammary glands. In general, women with a family history of larger breasts are more likely to have larger mammary glands themselves.

The percentage of fats and mammary glands in healthy women change as they grow older. As women age, their mammary glands tend to become less dense and more fatty, a process called involution. This is a normal physiological process and is not usually a cause for concern. Pregnancy and breastfeeding can also affect the size and shape of the mammary glands, causing them to become larger and more engorged with milk.

However, in some cases, changes in the size or density of the mammary glands can be a sign of a more serious underlying condition, such as breast cancer. It is important for women to perform regular breast self-exams and receive regular mammograms to detect any changes in the mammary glands and identify potential issues early on

Involution is the process by which the mammary gland returns to its non-lactating state after breastfeeding. The process of involution is affected by various factors including:

  1. Hormonal changes: The reduction in prolactin and oxytocin levels after breastfeeding stops triggers the process of involution.
  2. Age: The older a woman is, the more likely it is that her mammary gland will undergo incomplete involution.
  3. Number of pregnancies: Women who have had multiple pregnancies are more likely to experience incomplete involution compared to those who have had fewer pregnancies.
  4. Duration of lactation: Women who breastfeed for longer periods of time are more likely to experience complete involution compared to those who breastfeed for shorter periods.
  5. Health status: Certain medical conditions, such as mastitis or breast abscess, can interfere with the process of involution.
  6. Lifestyle factors: Smoking and obesity have been associated with incomplete involution in some studies.

The process of involution is complex and multifactorial, and is influenced by both intrinsic and extrinsic factors

Complete involution refers to the process where the mammary glands of a woman undergo a regression and return to a pre-pregnant state. It has been suggested that women with complete involution are less likely to develop breast cancer because during involution, the glandular tissue is replaced by fatty tissue, which may be less susceptible to malignant transformation.

In addition, during the process of involution, there is a rapid clearance of apoptotic cells and tissue remodeling, which may help eliminate potentially damaged or mutated cells that could lead to cancer development. Therefore, it is thought that incomplete involution, which results in persistent glandular tissue and incomplete clearance of apoptotic cells, may increase the risk of breast cancer

Incomplete involution of the mammary glands after pregnancy and lactation has been associated with an increased risk of breast cancer. However, there are no specific ovarian conditions that promote incomplete involution. Incomplete involution is a complex process that involves the interaction between multiple factors, including hormonal changes, inflammation, and tissue remodeling. Some studies have suggested that women with a history of ovarian stimulation for infertility treatment may have a higher risk of incomplete involution and breast cancer. Other factors that may contribute to incomplete involution include obesity, older age at first pregnancy, and certain genetic factors. However, further research is needed to fully understand the mechanisms underlying incomplete involution and its relationship with breast cancer risk.

There are several ovarian conditions that may promote obesity and result in glandular obesity. These include:

  1. Polycystic ovary syndrome (PCOS): This is a common hormonal disorder that affects women of reproductive age. Women with PCOS have high levels of male hormones (androgens) and insulin, which can lead to weight gain and glandular obesity.
  2. Ovarian tumors: Certain types of ovarian tumors, such as granulosa cell tumors and Sertoli-Leydig cell tumors, can produce high levels of androgens and lead to weight gain and glandular obesity.
  3. Ovarian hyperstimulation syndrome (OHSS): This condition can occur as a complication of fertility treatment, particularly with the use of medications to stimulate ovulation. OHSS can cause the ovaries to become enlarged and produce high levels of hormones, leading to weight gain and glandular obesity.
  4. Premature ovarian failure (POF): This is a condition in which the ovaries stop functioning before the age of 40. Women with POF may experience hormonal imbalances that can lead to weight gain and glandular obesity.

It’s worth noting that glandular obesity is not always caused by ovarian conditions, and that other factors such as diet, lifestyle, and genetics can also play a role in weight gain and obesity.

While BRCA1 and BRCA2 mutations can be inherited from a parent, they can also occur spontaneously as a result of errors that happen during cell division or due to environmental factors such as radiation or certain chemicals. However, inherited mutations in the BRCA1 and BRCA2 genes are associated with a significantly higher risk of developing breast and ovarian cancer

There are ongoing genetic engineering trials that aim to address BRCA1 and BRCA2 mutations in high-risk women. Some of these include:

  1. CRISPR gene editing: Researchers are using CRISPR gene editing to develop a treatment for BRCA1-related breast cancer. The technique involves introducing a synthetic DNA sequence that replaces the mutated BRCA1 gene with a functional one.
  2. Gene therapy: Another approach being studied is gene therapy, which involves introducing a healthy copy of the BRCA1 or BRCA2 gene into cells to restore their function. This can be done using viral vectors or other delivery methods.
  3. RNA interference: Researchers are also exploring the use of RNA interference (RNAi) to target and silence the mutated BRCA1 or BRCA2 genes. This approach involves using small RNA molecules to block the expression of specific genes.
  4. Synthetic lethality: Synthetic lethality is a strategy that takes advantage of the genetic vulnerabilities of cancer cells. Researchers are investigating ways to exploit synthetic lethality to selectively kill cancer cells with BRCA1 or BRCA2 mutations while sparing healthy cells.

It is important to note that these trials are still in the early stages of development and more research is needed to determine their safety and effectiveness

How RNA interference differ from Pfizer Covid19 vaccine?

RNA interference (RNAi) and the Pfizer COVID-19 vaccine are different in several ways. RNAi is a naturally occurring cellular process that regulates gene expression by suppressing the translation of specific messenger RNA molecules, whereas the Pfizer COVID-19 vaccine is a synthetic mRNA vaccine designed to provide immunity against the COVID-19 virus.

RNAi works by using small RNA molecules, called small interfering RNAs (siRNAs), to target and degrade specific mRNA molecules. This can be used to knock down the expression of disease-causing genes in cells. In contrast, the Pfizer COVID-19 vaccine uses a different type of mRNA molecule, called messenger RNA (mRNA), to provide instructions to the body’s cells to produce a harmless spike protein from the SARS-CoV-2 virus. This spike protein triggers an immune response that helps protect against COVID-19.

Additionally, RNAi has been used primarily for research purposes and has not yet been widely adopted for clinical use, although there are ongoing clinical trials for RNAi-based therapies. The Pfizer COVID-19 vaccine, on the other hand, has been authorized for emergency use by regulatory agencies and has been administered to millions of people worldwide.

mRNA vaccines, such as the Pfizer COVID-19 vaccine, introduce genetic material into the body. mRNA vaccines work by delivering a piece of genetic material from the virus to the body’s cells, which then produce a protein that triggers an immune response.


Verified by: Rami Diab (May 5, 2023)

Citation: Rami Diab. (May 5, 2023). Why women with Complete Involution are Less Likely to Develop Breast Cancer. Medcoi Journal of Medicine, 4(2). urn:medcoi:article22324.

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