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Thalassemia Thalassemia is a common genetic hemolytic disorder characterized by defective hemoglobin Hb synthesis and ineffective erythropoiesis, the disease is common in mideast-southeast africa (α Thalassemia 25%, clinics show in 10% of patients). Causes The defect in Hb synthesis is caused by one decreased globin polypeptide chain (β, α, γ, δ) β Thalassemia have two… Read More »

The Biochemistry of Coagulation Factors The biochemistry of coagulation factors in the blood clotting mechanism, and its function as a biochemical amplifier of blood coagulation was largely discovered in the 20th century. Paul Owren (1905–1990) discovered proaccelerin or Factor V in 1947, which was the first clue pointing to the complexity of the coagulation system…. Read More »

Hemophilia is an inherited blood clotting disorder in which the blood doesn’t clot normally. In most cases, it is caused by congenital factor viii/ix deficiency. However, about 35% of cases are caused by a spontaneous gene mutation. Read More »

Treatment should be directed toward relief of symptoms. Currently, most therapies used for bleeding disorder management are directed to prevent bleeding problems, in VWD this is accomplished by increasing the concentration of VWF and factor VIII (antihemophilic factor or AHF) simultaneously. Read More »

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