NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) and COX-2 (cyclooxygenase-2) are both pathways that play a role in the activation of the first stage of cellular senescence, which is a process by which cells stop dividing and enter a state of growth arrest. This stage is characterized by the activation of certain genes involved in inflammation and oxidative stress, as well as the production of pro-inflammatory cytokines…. Read More »