What is Azadirachtin and how it prevents pregnancy

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Neem Oil’s Active Ingredient (Azadirachtin) and Its Impact on the Reproductive Cycle in Females

Neem oil, derived from the seeds of the neem tree (Azadirachta indica), is known for its diverse biological activities. This research focuses on Azadirachtin, the primary active ingredient in neem oil, and elucidates its effects on the human reproductive cycle, particularly in females.

Active Ingredient: Azadirachtin Azadirachtin is a complex tetranortriterpenoid compound found in neem seeds. It is the key bioactive constituent responsible for neem oil’s various biological properties, including its contraceptive effects.

Mechanism of Action: The contraceptive actions of Azadirachtin are multi-faceted. It interferes with the reproductive process by inhibiting sperm function and viability. Azadirachtin is believed to impede the activity of enzymes crucial for fertilization, reducing the likelihood of successful sperm-egg interaction.

Impact on the Reproductive Cycle in Females:

  1. Ovulation Inhibition: Azadirachtin may influence the release of hormones that trigger ovulation. By modulating hormonal signals, it potentially inhibits the maturation and release of eggs from the ovaries.
  2. Alteration of Cervical Mucus: Azadirachtin is thought to affect the consistency and composition of cervical mucus. This alteration creates a hostile environment for sperm, hindering their mobility and ability to traverse the cervix.
  3. Endometrial Changes: The active ingredient may induce changes in the endometrial lining, making it less receptive to embryo implantation. This contributes to the overall contraceptive effect by preventing the establishment of a pregnancy.

Route of Action: Azadirachtin’s effects on the reproductive cycle occur locally, primarily within the female reproductive tract. Upon application, it is absorbed, and its bioactive components exert their influence on key processes involved in fertility.

Considerations for Safe Use: While neem oil, containing Azadirachtin, shows potential as a contraceptive, careful consideration is required. Individual responses may vary, and further research is essential to ascertain safety, dosage guidelines, and any potential long-term effects on the reproductive system.

This research provides insights into the active ingredient Azadirachtin in neem oil and its impact on the female reproductive cycle. Understanding the mechanism of action is crucial for evaluating the contraceptive potential of neem oil and its derivatives. Continued research will contribute to a comprehensive understanding of Azadirachtin’s role in fertility modulation and safe contraceptive practices

Azadirachtin: Daily Allowable Safe Dose, Side Effects, and Brand Names

  1. Daily Allowable Safe Dose:
    • As of the latest available information, there isn’t a universally established daily allowable safe dose for Azadirachtin in humans. Research on the specific dosage for contraceptive purposes or other applications is limited.
    • Safe dosages may vary based on the formulation, method of administration, and individual factors. To determine a safe dose, consultation with a healthcare professional or relevant regulatory guidelines is recommended.
  2. Side Effects:
    • Limited human studies on Azadirachtin’s side effects make it challenging to compile a comprehensive list. Potential side effects may include gastrointestinal discomfort, allergic reactions, or skin irritation.
    • Extended use or excessive exposure could lead to more pronounced adverse effects, emphasizing the importance of cautious application and monitoring.
  3. Brand Names:
    • Azadirachtin itself is not typically sold directly to consumers under a specific brand name. Neem oil, the source of Azadirachtin, may be available from various manufacturers or distributors.
    • Neem-based products, including those containing Azadirachtin, might be marketed under different brand names. Commonly, these are identified as neem oil or neem-based formulations.

Important Considerations:

  • It is crucial to use neem-based products or Azadirachtin-containing formulations as per the manufacturer’s instructions.
  • Adverse effects and safe dosages may differ based on the specific product, concentration, and intended use (e.g., agricultural, cosmetic, or medicinal).
  • Individuals with allergies to neem or related compounds should exercise caution and consult a healthcare professional before using products containing Azadirachtin.

Note: It’s advisable to consult a healthcare professional for dosaging.


Verified by: Dr.Diab (December 19, 2023)

Citation: Dr.Diab. (December 19, 2023). What is Azadirachtin and how it prevents pregnancy. Medcoi Journal of Medicine, 3(2). urn:medcoi:article22457.

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