Higher levels of body fat can lead to an earlier onset of menarche in girls through multiple mechanisms, including the production of leptin, which stimulates the hypothalamus to produce GnRH, and the effects of insulin resistance on IGF-1 production… Read More »


Obesity can lead to excess cortisol production due to the relationship between adipose (fat) tissue and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol production. Adipose tissue produces several hormones, including leptin, which signals to the hypothalamus to stimulate the HPA axis and increase cortisol production…. Read More »


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